About   Help   FAQ
Arfgef2tm1Itl
Targeted Allele Detail
Nomenclature
Symbol: Arfgef2tm1Itl
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); targeted mutation 1, inGenious Targeting Laboratory
MGI ID: MGI:5440903
Gene: Arfgef2  Location: Chr2:166805588-166898052 bp, + strand  Genetic Position: Chr2, 87.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187673
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 5 were replaced with an FRT- and loxP flanked neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:187673)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arfgef2 Mutation:  5 strains or lines available
References
Original:  J:187673 Zhang J, et al., Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory