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Wnk1tm2Cihu
Targeted Allele Detail
Summary
Symbol: Wnk1tm2Cihu
Name: WNK lysine deficient protein kinase 1; targeted mutation 2, Chou-Long Huang
MGI ID: MGI:5440881
Synonyms: KS-WNK1-KO
Gene: Wnk1  Location: Chr6:119900930-120015633 bp, - strand  Genetic Position: Chr6, 56.86 cM
Alliance: Wnk1tm2Cihu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:168700
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exon 4a. Northern blot analysis confirmed the absence of transcript expression of the kidney-specific (KS) isoform. (J:168700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnk1 Mutation:  113 strains or lines available
References
Original:  J:168700 Liu Z, et al., Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet. 2011 Mar 1;20(5):855-66
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory