Braf^tm2Cpri
Targeted Allele Detail

Summary

• Symbol: Braf^tm2Cpri
• Name: Braf transforming gene; targeted mutation 2, Catrin Pritchard
• MGI ID: MGI:5440045
• Synonyms: Braf^LSL-L597V
• Gene: Braf Location: Chr6:39580171-39702397 bp, - strand Genetic Position: Chr6, 18.43 cM
• Alliance: Braf^tm2Cpri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187371
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 15 was replaced with a floxed neo/STOP cassette and a modified exon 15 in which a C to A transversion (C1789A) results in the amino acid substitution of valine for leucine at position 597 (L579V). (J:187371)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Braf Mutation: 58 strains or lines available

References

• Original: J:187371 Andreadi C, et al., The intermediate-activity L597VBRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev. 2012 Sep 1;26(17):1945-58
• All: 3 reference(s)