Rnf43^tm1Cle
Targeted Allele Detail

Summary

• Symbol: Rnf43^tm1Cle
• Name: ring finger protein 43; targeted mutation 1, Hans Clevers
• MGI ID: MGI:5439364
• Gene: Rnf43 Location: Chr11:87553913-87626365 bp, + strand Genetic Position: Chr11, 52.17 cM
• Alliance: Rnf43^tm1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the exons encoding the RING finger domain and a loxP site and FRT flanked neo cassette were inserted downstream of these exons via homologous recombination. (J:186765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf43 Mutation: 34 strains or lines available

References

• Original: J:186765 Koo BK, et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012 Aug 30;488(7413):665-9
• All: 6 reference(s)