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Targeted Allele Detail
Symbol: Mlc1tm1Rhn
Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human); targeted mutation 1, Rene Hen
MGI ID: MGI:5439272
Synonyms: Mlc1 STOP-tetO
Gene: Mlc1  Location: Chr15:88955884-88979007 bp, - strand  Genetic Position: Chr15, 44.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:159353
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site was inserted upstream of the translation initiation site. In situ hybridization confirmed the absence of transcript expression. (J:159353)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mlc1 Mutation:  13 strains or lines available
Original:  J:159353 Tanaka KF, et al., Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry. 2010 Apr 15;67(8):770-3
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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