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Targeted Allele Detail
Symbol: Ago4tm1.1Peco
Name: argonaute RISC catalytic subunit 4; targeted mutation 1.1, Paula E Cohen
MGI ID: MGI:5438526
Gene: Ago4  Location: Chr4:126383334-126427265 bp, - strand  Genetic Position: Chr4, 60.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:187588
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted in intron 2 and an FRT flanked pgk-neo cassette and loxP site were inserted into intron 17 via homologous recombination. Recombinase mediated recombination removed exons 3-17 and the neo cassette. (J:187588)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ago4 Mutation:  28 strains or lines available
Original:  J:187588 Modzelewski AJ, et al., AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline. Dev Cell. 2012 Aug 14;23(2):251-64
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory