Timd4^tm1Osa
Targeted Allele Detail

Summary

• Symbol: Timd4^tm1Osa
• Name: T cell immunoglobulin and mucin domain containing 4; targeted mutation 1, Shigekazu Nagata
• MGI ID: MGI:5438219
• Gene: Timd4 Location: Chr11:46701627-46735159 bp, + strand Genetic Position: Chr11, 28.09 cM
• Alliance: Timd4^tm1Osa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187181
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and most of exon 2 were replaced with a cassette containing Venus and neo genes. Cell sorting confirmed the absence of protein expression in peritoneal macrophages. (J:187181)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timd4 Mutation: 27 strains or lines available

References

• Original: J:187181 Miyanishi M, et al., Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol. 2012 Sep;24(9):551-9
• All: 13 reference(s)