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Pik3catm1Gilb
Targeted Allele Detail
Nomenclature
Symbol: Pik3catm1Gilb
Name: phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; targeted mutation 1, Richard Gilbertson
MGI ID: MGI:5438138
Synonyms: Pik3caE545K
Gene: Pik3ca  Location: Chr3:32397671-32466107 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186709
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed puro/STOP cassette was inserted upstream of the exon containing the initiation codon. Exon 9 was replaced with one in which nucleotide substitution results in the amino acid substitution of lysine for glutamic acid at position 545 (E545K). Flp-mediated recombination removed the floxed neo cassette inserted into intron 9. Cre-mediated recombination is required to achieve expression of the knock-in allele. (J:186709)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  14 strains or lines available
References
Original:  J:186709 Robinson G, et al., Novel mutations target distinct subgroups of medulloblastoma. Nature. 2012 Aug 2;488(7409):43-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory