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b2b1117.1Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1117.1Clo
Name: Mutant line 1117.1; Bench to Bassinet Program (B2B/CVDC), mutation 1117, subline 1 Cecilia Lo
MGI ID: MGI:5437731
Gene: b2b1117.1Clo  Location: unknown  
Mutant 1117-007-NA shows a single great artery arising from ventricles with right sided aortic arch

Show the 9 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b1117Clo. The molecular lesion is in the Kif15 gene. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1117.1Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1117.1Clo Mutation:  1 strain or line available
Notes
This mutation was derived from the parent line b2b1117Clo.

Summative Diagnosis:
Mutant Type 1:
Cardiac phenotype: Pulmonary atresia, ventricular septal defect (VSD) and major aortopulmonary collateral arteries (MAPCA)
Noncardiac phenotype: Facial cleft, micrognathia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
1000 Pulmonary atresia congenital
1300 Ventricular septal defect
2771 Multiple major aortopulmonary collateral arteries (mapcas)
4163 Micrognathia

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory