About   Help   FAQ
b2b227Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b227Clo
Name: Mutant line 227; Bench to Bassinet Program (B2B/CVDC), mutation 227 Cecilia Lo
MGI ID: MGI:5437098
Synonyms: Scrappy
Gene: b2b227Clo  Location: unknown  
Mutant 227-002-NC exhibits dextrocardia with duplicated inferior vena cava (IVC)

Show the 11 image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b227Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Mutant Type 1:
Cardiac phenotype: Congenital heart disease associated with heterotaxy such as double outlet right ventricle (DORV) with subaortic ventricular septal defect (VSD), dextrocardia/mesocardia.
Noncardiac phenotype: dextrogastria, hypoplastic spleen, cystic lung, immotile/slow/dyskinetic cilia

Mutant Type 2: Biventricular hypertrophy

Phenotypic Similarity to Human Syndrome:
Mutant Type 1: Heterotaxy, Kartagener's syndrome, Primary ciliary dyskinesia
Mutant Type 2: Cardiac hypertrophy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
0110 Dextrocardia
0140 Mesocardia
0190 Heterotaxy Syndrome
0600 Double outlet right ventricle
1300 Ventricular septal defect
1845 Hypertrophic cardiomyopathy
3804 Congenital heart disease
3950 {S,D,D}
3973 {I,L,L}
3988 {A,L,L}
4200 Respiratory anomaly
7505 Biventricular hypertrophy

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission (B2B/CvDC). 2011-13;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/15/2014
MGI 5.17
The Jackson Laboratory