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Targeted Allele Detail
Symbol: Porcntm1.1Vdv
Name: porcupine homolog (Drosophila); targeted mutation 1.1, Ignatia B Van den Veyver
MGI ID: MGI:5435556
Synonyms: Porcn-ex3-7flox
Gene: Porcn  Location: ChrX:8193848-8206525 bp, - strand  Genetic Position: ChrX, 3.7 cM
Skeletal abnormalities in Porcntm1.1Vdv/Y Tg(Prrx1-cre)1Cjt/0 mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:186934
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 7. Flp mediated recombination removed the neo cassette. (J:186934)
Generation of Porcn targeted alleles
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Porcn Mutation:  15 strains or lines available
Original:  J:186934 Liu W, et al., Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One. 2012;7(3):e32331
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory