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Targeted Allele Detail
Symbol: Porcntm1Vdv
Name: porcupine O-acyltransferase; targeted mutation 1, Ignatia B Van den Veyver
MGI ID: MGI:5435555
Synonyms: Porcn-ex3-7Neo-flox
Gene: Porcn  Location: ChrX:8193848-8206525 bp, - strand  Genetic Position: ChrX, 3.7 cM
Digit, vertebral, kidney, and reproductive system abnormalities in Porcntm1Vdv/Y and Porcntm1Vdv/Porcn+ chimeras

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:186934
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 7. (J:186934)
Generation of Porcn targeted alleles
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Porcn Mutation:  16 strains or lines available
Original:  J:186934 Liu W, et al., Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One. 2012;7(3):e32331
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory