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Tg(Thy1-SNCA)61Ema
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-SNCA)61Ema
Name: transgene insertion 61, Eliezer Masliah
MGI ID: MGI:5435401
Synonyms: ASOTg, mThy-1-alpha-synuclein, mThy-1 tg
Transgene: Tg(Thy1-SNCA)61Ema  Location: unknown  Genetic Position: ChrX, Syntenic
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-SNCA)61Ema expresses 1 gene
 
Mutation detailsThis transgene contains a human wild-type alpha synuclein fragment (nt 53-475) under the control of the mouse Thy1 promoter. Lines 61 was generated. Transgene expression is seen throughout the brain, including the basal ganglia, thalamus, substantia nigra, and brainstem. (J:137490)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:137490 Rockenstein E, et al., Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res. 2002 Jun 1;68(5):568-78
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory