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Targeted Allele Detail
Symbol: Slc5a1tm1.1Koep
Name: solute carrier family 5 (sodium/glucose cotransporter), member 1; targeted mutation 1.1, Hermann Koepsell
MGI ID: MGI:5433400
Synonyms: Sglt1-
Gene: Slc5a1  Location: Chr5:33104219-33162872 bp, + strand  Genetic Position: Chr5, 17.46 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:186790
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was flanked by a floxed neo cassette and an additional loxP site. Cre-mediated recombination removed the neo cassette and exon 1. Western blot analysis of brush border membrane vesicles confirmed the absence of protein expression. (J:186790)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc5a1 Mutation:  16 strains or lines available
Original:  J:186790 Gorboulev V, et al., Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012 Jan;61(1):187-96
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory