Slc5a1^tm1.1Koep
Targeted Allele Detail

Summary

• Symbol: Slc5a1^tm1.1Koep
• Name: solute carrier family 5 (sodium/glucose cotransporter), member 1; targeted mutation 1.1, Hermann Koepsell
• MGI ID: MGI:5433400
• Synonyms: Sglt1^-
• Gene: Slc5a1 Location: Chr5:33261563-33320043 bp, + strand Genetic Position: Chr5, 17.46 cM, cytoband B1
• Alliance: Slc5a1^tm1.1Koep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was flanked by a floxed neo cassette and an additional loxP site. Cre-mediated recombination removed the neo cassette and exon 1. Western blot analysis of brush border membrane vesicles confirmed the absence of protein expression. (J:186790)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a1 Mutation: 53 strains or lines available

References

• Original: J:186790 Gorboulev V, et al., Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012 Jan;61(1):187-96
• All: 16 reference(s)