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Targeted Allele Detail
Symbol: Fezf2tm1.1Nses
Name: Fez family zinc finger 2; targeted mutation 1.1, Nenad Sestan
MGI ID: MGI:5433045
Synonyms: Fezf2fl
Gene: Fezf2  Location: Chr14:12341892-12345865 bp, - strand  Genetic Position: Chr14, 6.36 cM
Aberrant L6 projections to the brainstem in the Tbr1tm1Jlr/Tbr1tm1Jlr mice require Fezf2

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:169221
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:169221)
Generation of the Fezf2tm1.1Nses allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fezf2 Mutation:  23 strains or lines available
Original:  J:169221 Han W, et al., TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3041-6
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory