Fezf2^tm1.1Nses
Targeted Allele Detail

Summary

• Symbol: Fezf2^tm1.1Nses
• Name: Fez family zinc finger 2; targeted mutation 1.1, Nenad Sestan
• MGI ID: MGI:5433045
• Synonyms: Fezf2^fl
• Gene: Fezf2 Location: Chr14:10121574-10127669 bp, + strand Genetic Position: Chr14, 6.36 cM
• Alliance: Fezf2^tm1.1Nses page

Aberrant L6 projections to the brainstem in the Tbr1^tm1Jlr/Tbr1^tm1Jlr mice require Fezf2

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169221
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:169221)

Generation of the Fezf2^tm1.1Nses allele

Expression

In Mice Carrying this Mutation:	16 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fezf2 Mutation: 49 strains or lines available

References

• Original: J:169221 Han W, et al., TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3041-6
• All: 10 reference(s)