Cpt1c^tm1Fghe
Targeted Allele Detail

Summary

• Symbol: Cpt1c^tm1Fghe
• Name: carnitine palmitoyltransferase 1c; targeted mutation 1, Fausto G Hegardt
• MGI ID: MGI:5432790
• Gene: Cpt1c Location: Chr7:44608796-44624275 bp, - strand Genetic Position: Chr7, 29.07 cM, cytoband B2
• Alliance: Cpt1c^tm1Fghe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186508
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 12 through 15 were deleted. Western blot analysis confirmed the absence of protein expression in the microsomes and mitochondria hippocampal neurons. (J:186508)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1c Mutation: 42 strains or lines available

References

• Original: J:186508 Carrasco P, et al., Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem. 2012 Jun 15;287(25):21224-32
• All: 10 reference(s)