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Tg(tetO-IGF1R)1Ramo
Transgene Detail
Nomenclature
Symbol: Tg(tetO-IGF1R)1Ramo
Name: transgene insertion 1, Roger A Moorehead
MGI ID: MGI:5432255
Synonyms: TRE-IGF1R1
Transgene: Tg(tetO-IGF1R)1Ramo  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-IGF1R)1Ramo expresses 1 gene
 
Mutation detailsThe tetracycline response element (TRE or tetO) was used to drive inducible expression of the full-length human IGF1R. In double transgenic mice also expressing the tetracycline transactivating or reverse transactivating element (tTA or rtTA), expression of IGF1R can be regulated by doxycycline administration or removal. Four lines were created. (J:121069)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:121069 Jones RA, et al., Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007 Mar 8;26(11):1636-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory