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Nxnl1tm1.2Tlev
Targeted Allele Detail
Nomenclature
Symbol: Nxnl1tm1.2Tlev
Name: nucleoredoxin-like 1; targeted mutation 1.2, Thierry Leveillard
MGI ID: MGI:5432155
Gene: Nxnl1  Location: Chr8:71560555-71566601 bp, - strand  Genetic Position: Chr8, 34.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186370
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT flanked neo cassette with a 5' losP site was inserted downstream of exon 1. FLP mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1. Western blot analysis confirmed the abscence of protein expression in the retina. (J:186370)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nxnl1 Mutation:  8 strains or lines available
References
Original:  J:186370 Cronin T, et al., The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress. Cell Death Differ. 2010 Jul;17(7):1199-210
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory