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Targeted Allele Detail
Symbol: Clrn1tm2.1Kuna
Name: clarin 1; targeted mutation 2.1, Kumar N Alagramam
MGI ID: MGI:5432130
Synonyms: Clrn1N48K
Gene: Clrn1  Location: Chr3:58844028-58885340 bp, - strand  Genetic Position: Chr3, 28.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:186316
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 x C57BL/6J
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsExon 1 was replaced with one in which a point mutation (C to G) results in the amino acid substitution of lysine for asparagine (N48K). The floxed neo cassette inserted downstream of the modified exon 1 was removed by cre mediated recombination. (J:186316)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clrn1 Mutation:  8 strains or lines available
Original:  J:186316 Geng R, et al., The Mechanosensory Structure of the Hair Cell Requires Clarin-1, a Protein Encoded by Usher Syndrome III Causative Gene. J Neurosci. 2012 Jul 11;32(28):9485-9498
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory