About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Ryr2tm1.1Clhh
Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Christopher Huang
MGI ID: MGI:5432111
Synonyms: RyR2P2328S, RyR2s
Gene: Ryr2  Location: Chr13:11553103-12106945 bp, - strand  Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
Germline Transmission:  Earliest citation of germline transmission: J:186379
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 45 was replaced with one in which nucleotide substitutions (CCC to TCT) result in the amino acid substitution of serine for proline at 2328 (P2328S). A floxed neo cassette inserted downstream of exon 45 was removed by cre mediated recombination. (J:186379)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ryr2 Mutation:  35 strains or lines available
Original:  J:186379 Goddard CA, et al., Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts. Acta Physiol (Oxf). 2008 Oct;194(2):123-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory