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Targeted Allele Detail
Symbol: Vps18tm1.1Wtao
Name: VPS18 CORVET/HOPS core subunit; targeted mutation 1.1, Wufan Tao
MGI ID: MGI:5431976
Synonyms: Vsp18F
Gene: Vps18  Location: Chr2:119288740-119298453 bp, + strand  Genetic Position: Chr2, 59.97 cM
Small size of Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 mice at P10

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:186307
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsFlp-mediated recombination removed the lacZ reporter gene and neo cassette. Exons 3 and 4 remain floxed. (J:186307)
Generation of the Vps18tm1Wtao and Vps18tm1.1Wtao alleles
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vps18 Mutation:  11 strains or lines available
Original:  J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Aug 1;
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory