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Targeted Allele Detail
Symbol: Vps18tm1.1Wtao
Name: VPS18 CORVET/HOPS core subunit; targeted mutation 1.1, Wufan Tao
MGI ID: MGI:5431976
Synonyms: Vsp18F
Gene: Vps18  Location: Chr2:119288742-119298453 bp, + strand  Genetic Position: Chr2, 59.97 cM
Small size of Vps18tm1.1Wtao/Vps18tm1.1Wtao Tg(Nes-cre)1Kln/0 mice at P10

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:186307
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsFlp-mediated recombination removed the lacZ reporter gene and neo cassette. Exons 3 and 4 remain floxed. (J:186307)
Generation of the Vps18tm1Wtao and Vps18tm1.1Wtao alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vps18 Mutation:  25 strains or lines available
Original:  J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21;287(39):32861-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory