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Targeted Allele Detail
Symbol: Fig4tm1.1Mm
Name: FIG4 phosphoinositide 5-phosphatase; targeted mutation 1.1. Miriam H Meisler
MGI ID: MGI:5431009
Synonyms: Fig4flox
Gene: Fig4  Location: Chr10:41188172-41303241 bp, - strand  Genetic Position: Chr10, 22.08 cM
Germline Transmission:  Earliest citation of germline transmission: J:185989
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxZP site was inserted upstream of exon 4 and another loxP site was placed downstream along with an FRT flanked neo cassette immediately 3'. Th neo cassette was subsequently removed by crossing to flp expressing mice. No protein product was detected by Western blot in exon 4 deleted mice. (J:185989)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fig4 Mutation:  32 strains or lines available
Original:  J:185989 Ferguson CJ, et al., Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet. 2012 Aug 15;21(16):3525-34
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory