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Transgenic Allele Detail
Symbol: Ak7Tg(tetO-Hmox1)67Sami
Name: adenylate kinase 7; transgene insertion 67, S Alex Mitsialis
MGI ID: MGI:5431002
Synonyms: TH67
Gene: Ak7  Location: Chr12:105705982-105782447 bp, + strand  Genetic Position: Chr12, 55.95 cM, cytoband F1
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Ak7Tg(tetO-Hmox1)67Sami expresses 1 gene
Mutation detailsA transgene containing a tetracycline responsive promoter driving expression of Hmox1 inserted into intron 5 in line 67. A T:A base pair deletion was also detected in exon 4 that results in a frameshift mutation. RT-PCR confirmed the absence of endogenous gene transcript expression. (J:186062)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ak7 Mutation:  141 strains or lines available
Phenotypic Similarity to Human Syndrome: Ciliary Dyskinesia, Primary (J:186062)
Original:  J:186062 Fernandez-Gonzalez A, et al., Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar;40(3):305-13
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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