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Targeted Allele Detail
Symbol: Spg20tm1.1Xen
Name: spastic paraplegia 20, spartin (Troyer syndrome) homolog (human); targeted mutation 1.1, Taconic Biosciences
MGI ID: MGI:5430946
Gene: Spg20  Location: Chr3:55112108-55137322 bp, + strand  Genetic Position: Chr3, 26.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:185987
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 and all of exons 3 through 5 were replaced with a luciferase reporter and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain, spinal cord and testis. (J:185987)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spg20 Mutation:  8 strains or lines available
Original:  J:185987 Renvoise B, et al., Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet. 2012 Aug 15;21(16):3604-18
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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