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Targeted Allele Detail
Symbol: Tcf7l2tm2.1Cle
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.1, Hans Clever
MGI ID: MGI:5430317
Synonyms: Tcf4LoxP
Gene: Tcf7l2  Location: Chr19:55741820-55933654 bp, + strand  Genetic Position: Chr19, 51.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:185753
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:185753)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  21 strains or lines available
Original:  J:185753 van Es JH, et al., A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol Cell Biol. 2012 May;32(10):1918-27
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory