About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Tcf7l2tm2.1Cle
Targeted Allele Detail
Nomenclature
Symbol: Tcf7l2tm2.1Cle
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 2.1, Hans Clever
MGI ID: MGI:5430317
Synonyms: Tcf4LoxP
Gene: Tcf7l2  Location: Chr19:55741820-55933654 bp, + strand  Genetic Position: Chr19, 51.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185753
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:185753)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  17 strains or lines available
References
Original:  J:185753 van Es JH, et al., A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Mol Cell Biol. 2012 May;32(10):1918-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory