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Vangl2tm1.2Mdea
Targeted Allele Detail
Summary
Symbol: Vangl2tm1.2Mdea
Name: VANGL planar cell polarity 2; targeted mutation 1.2, Michael R Deans
MGI ID: MGI:5430219
Synonyms: vangl2deltaTMs
Gene: Vangl2  Location: Chr1:171828527-171856011 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance: Vangl2tm1.2Mdea page
Neural tube defects in Vangl2tm1.2Mdea/Vangl2tm1.2Mdea mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185311
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and flp-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in brain lysates. (J:185311)
Generation of the Vangl2tm1.2Mdea allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vangl2 Mutation:  34 strains or lines available
References
Original:  J:185311 Yin H, et al., Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One. 2012;7(2):e31988
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory