Fzd3^tm1(FZD3)Lex
Targeted Allele Detail

Summary

• Symbol: Fzd3^tm1(FZD3)Lex
• Name: frizzled class receptor 3; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5429212
• Synonyms: Tg(FZD3)1Lex
• Gene: Fzd3 Location: Chr14:65429898-65499912 bp, - strand Genetic Position: Chr14, 34.09 cM
• Alliance: Fzd3^tm1(FZD3)Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185566
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Fzd3^tm1(FZD3)Lex expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FZD3 (7976)

  Fzd3	(MGI:108476)

• Coding exon 1 was replaced with a full-length human FZD3 cDNA. (J:185566)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzd3 Mutation: 32 strains or lines available

References

• Original: J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
• All: 1 reference(s)