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Fzd3tm1(FZD3)Lex
Targeted Allele Detail
Nomenclature
Symbol: Fzd3tm1(FZD3)Lex
Name: frizzled homolog 3 (Drosophila); targeted mutation 1, Lexicon Genetics
MGI ID: MGI:5429212
Synonyms: Tg(FZD3)1Lex
Gene: Fzd3  Location: Chr14:65201026-65262463 bp, - strand  Genetic Position: Chr14, 34.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185566
Parent Cell Line:  Lex-2 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
    Coding exon 1 was replaced with a full-length human FZD3 cDNA. (J:185566)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fzd3 Mutation:  7 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hydrocephalus in homozygous mice (J:185566)

References
Original:  J:185566 Vogel P, et al., Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012 Jan;49(1):166-81
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory