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Tg(Pklr-Myc)73Ak
Transgene Detail
Nomenclature
Symbol: Tg(Pklr-Myc)73Ak
Name: transgene insertion 73, Axel Kahn
MGI ID: MGI:5428913
Synonyms: L-PK/c-myc73
Transgene: Tg(Pklr-Myc)73Ak  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a 2.4 kb fragment containing exons 2 and 3 of the murine c-myc oncogene under the control of the rat L-type pyruvate kinase gene regulatory region. The 3' UTR of the Myc gene was replaced with the 3' UTR region of SV40 early gene to enhance stability of myc mRNA. Transcription of Pklr is dependent on metabolic and hormonal controls, such that glucose and insulin increase transcription, while fasting, refeeding a low-carbohydrate diet and glucagon inhibit Pklr transcription. Thus manipulation of diet can result in expression of the transgene. Line 73 carries approximately 100 copies of the transgene. Northern blot analysis indicates transgene expression in the liver and to a lesser degree in the small intestine and kidney. (J:185488)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:185488 Cartier N, et al., Diet-dependent carcinogenesis of pancreatic islets and liver in transgenic mice expressing oncogenes under the control of the L-type pyruvate kinase gene promoter. Oncogene. 1992 Jul;7(7):1413-22
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory