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Arap3tm1.1Sve
Targeted Allele Detail
Nomenclature
Symbol: Arap3tm1.1Sve
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; targeted mutation 1.1, Sonja Vermeren
MGI ID: MGI:5428753
Synonyms: Arap3fl
Gene: Arap3  Location: Chr18:37972628-37998969 bp, - strand  Genetic Position: Chr18, 19.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185401
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 5 and an FRT flanked neo cassette and loxP site were inserted in intron 8 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185401)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arap3 Mutation:  0 strains or lines available
References
Original:  J:185401 Gambardella L, et al., PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal. 2010;3(145):ra76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory