Stk38^tm1Hem
Targeted Allele Detail

Summary

• Symbol: Stk38^tm1Hem
• Name: serine/threonine kinase 38; targeted mutation 1, Brian A Hemmings
• MGI ID: MGI:5428694
• Synonyms: NDR1^-
• Gene: Stk38 Location: Chr17:29189854-29226969 bp, - strand Genetic Position: Chr17, 15.03 cM
• Alliance: Stk38^tm1Hem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185408
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/Ola

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES/lacZ/neo cassette was inserted into exon 4. Western blot analysis confirmed the absence of protein expression in thymus extracts. (J:185408)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk38 Mutation: 54 strains or lines available

References

• Original: J:185408 Cornils H, et al., Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma. Sci Signal. 2010;3(126):ra47
• All: 4 reference(s)