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Targeted Allele Detail
Symbol: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno
Name: hypoxanthine guanine phosphoribosyl transferase; targeted mutation 1, Genoway
MGI ID: MGI:5428335
Synonyms: PLB1
Gene: Hprt  Location: ChrX:52988137-53021659 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Germline Transmission:  Earliest citation of germline transmission: J:180977
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno expresses 2 genes
Mutation detailsA construct containing the Camk2a promoter, loxP site, human APP cDNA with the Sweden and London mutations (K670N, M671L and V717I), FRT site, IRES, loxP site, human MAPT cDNA with P301L and R406W mutations, FRT site and neo cassette was inserted into the locus. (J:180977)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt Mutation:  30 strains or lines available
Original:  J:180977 Platt B, et al., Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PLoS One. 2011;6(11):e27068
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory