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Tg(Prnp*)#Rgab
Transgene Detail
Nomenclature
Symbol: Tg(Prnp*)#Rgab
Name: transgene insertion, Ruth Gabizon
MGI ID: MGI:5428331
Synonyms: TgMHu2ME199K, (TgMHu2M) E199KPrP, TgMHu2ME200K
Transgene: Tg(Prnp*)#Rgab  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp*)#Rgab expresses 1 gene
 
Mutation detailsThe Syrian hamster promoter drives expression of the chimeric mouse/human cDNA MHu2M containing nucleotide substitutions that results in the amino acid substitutions of methionine for leucine at position 108, methionine for valine at position 111, methionine for isoleucine at position 138, asparagine for tyrosine at position 154, asparagine for serine at position 169 with the additional substitution of lysine for glutamic acid at position 199. This mutation corresponds to the human mutation E200K associated with Creutzfeldt-Jakob disease. Two lines were generated. The pound symbol (#) is used when no line is specified or lines or pooled. (J:183170)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
This transgene was originally generated in oocytes containing Prnptm1Cwe.

References
Original:  J:183170 Friedman-Levi Y, et al., Fatal prion disease in a mouse model of genetic E200K Creutzfeldt-Jakob disease. PLoS Pathog. 2011 Nov;7(11):e1002350
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory