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Targeted Allele Detail
Symbol: Gata4tm1Grg
Name: GATA binding protein 4; targeted mutation 1, Vidu Garg
MGI ID: MGI:5427934
Synonyms: Gata4 G295Ski
Gene: Gata4  Location: Chr14:63198922-63271692 bp, - strand  Genetic Position: Chr14, 33.24 cM
Growth retardation and a thin myocardium in Gata4tm1Grg/Gata4tm1Grg mice

Show the 9 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:185124
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Humanized sequence, Hypomorph)
Mutations:    Insertion, Single point mutation
Mutation detailsA G to A mutation was introduced in exon 3 creating a glycine to serine substitution (G295S) and a floxed neo cassette was inserted downstream of exon 4 via homologous recombination. Immunoblot analysis indicated that protein levels in homozygous mice are similar to wild-type. (J:185124)
Targeting strategy for generation of Gata4tm1Grg knock-in allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  23 strains or lines available
Original:  J:185124 Misra C, et al., Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012 May;8(5):e1002690
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory