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Tg(Ckm-CUGBP1)1039Coop
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-CUGBP1)1039Coop
Name: transgene insertion 1039, Thomas A Cooper
MGI ID: MGI:5427873
Synonyms: MCKCUG-BP1
Transgene: Tg(Ckm-CUGBP1)1039Coop  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-CUGBP1)1039Coop expresses 1 gene
 
Mutation detailsA human CUGBP1, 'A' form, clone, containing an N-terminal FLAG epitope tag, was expressed in mice under the control of a mouse creatine kinase (MCK) promoter, enhancer, the untranslated exon 1, and intron 1 and bovine growth hormone 3' flanking genomic segment for proper mRNA 3' end formation. In addition to line 1039, linse 1032 and 1036 were also established. Western blot analysis showed that transgene expression is approximately 4-6 fold above endogenous levels. (J:99370)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:99370 Ho TH, et al., Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy. Hum Mol Genet. 2005 Jun 1;14(11):1539-47
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory