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Targeted Allele Detail
Symbol: Pik3catm1.1Waph
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Wayne A Phillips
MGI ID: MGI:5427579
Synonyms: Pik3caH1047R, Pik3caLat-H1047R
Gene: Pik3ca  Location: Chr3:32397671-32468486 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Hyperproliferation of the ovarian surface epithelium in Pik3catm1.1Waph/Pik3catm1.1Waph mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:184382
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 20 was floxed. An addtional modified exon 20 was inserted downstream of the endogenous exon. The modified exon 20 contains nucleotide substitutions (CAT to AGG) that result in the amino acid substitution of arginine for histidine at position 1047 (H1047R). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:184382)
Generation of the Pik3catm1.1Waph allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  19 strains or lines available
Original:  J:184382 Kinross KM, et al., An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice. J Clin Invest. 2012 Feb 1;122(2):553-7
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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