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Apoetm2(APOE_i3)Yhg
Targeted Allele Detail
Nomenclature
Symbol: Apoetm2(APOE_i3)Yhg
Name: apolipoprotein E; targeted mutation 2, Yadong Huang
MGI ID: MGI:5427462
Synonyms: ApoE3-fKI, E3+
Gene: Apoe  Location: Chr7:19696109-19699166 bp, - strand  Genetic Position: Chr7, 9.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184138
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding sequence (exons 2 through 4) was replaced with the corresponding human genomic sequence encoding isoform 3. A loxP site was inserted 5' of the human sequence and a neo cassette with a 5' loxP site was inserted downstream of the human sequence. (J:184138)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  57 strains or lines available
References
Original:  J:184138 Bien-Ly N, et al., Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci. 2012 Apr 4;32(14):4803-11
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory