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Tmc2tm1.1Ajg
Targeted Allele Detail
Nomenclature
Symbol: Tmc2tm1.1Ajg
Name: transmembrane channel-like gene family 2; targeted mutation 1.1, Andrew J Griffith
MGI ID: MGI:5427099
Synonyms: Tmc2delta
Gene: Tmc2  Location: Chr2:130037114-130106365 bp, + strand  Genetic Position: Chr2, 63.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184419
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 7 was replaced with an IRES-lacZ cassette and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. At P28 beta-galactosidase activity is detected in hair cells of the cristae ampullaris and very faintly in in hair cells of the saccular and utricular maculae. (J:184419)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmc2 Mutation:  30 strains or lines available
References
Original:  J:184419 Kawashima Y, et al., Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 2011 Dec;121(12):4796-809
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory