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Targeted Allele Detail
Symbol: Pbx1tm1.1Koss
Name: pre B cell leukemia homeobox 1; targeted mutation 1.1, Matthew J Koss
MGI ID: MGI:5426974
Synonyms: Pbx1deltaneo
Gene: Pbx1  Location: Chr1:168119364-168432264 bp, - strand  Genetic Position: Chr1, 75.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:184521
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:184521)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  18 strains or lines available
Original:  J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory