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Targeted Allele Detail
Symbol: Rgs7tm1Cjch
Name: regulator of G protein signaling 7; targeted mutation 1, Ching-Kang Chen
MGI ID: MGI:5426905
Gene: Rgs7  Location: Chr1:175059087-175492500 bp, - strand  Genetic Position: Chr1, 81.11 cM
Rgs7tm1Cjch/Rgs7tm1Cjch Rgs11tm1Lex/Rgs11tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:184922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neo cassette replaced exons 6 through 8. Western blot analysis confirmed the absence of protein expression in the retina and cerebellum. (J:184922)
Generation of the Rgs7tm1Cjch allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs7 Mutation:  16 strains or lines available
Original:  J:184922 Shim H, et al., Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem. 2012 Apr 27;287(18):14873-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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