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Rgs7tm1Cjch
Targeted Allele Detail
Nomenclature
Symbol: Rgs7tm1Cjch
Name: regulator of G protein signaling 7; targeted mutation 1, Ching-Kang Chen
MGI ID: MGI:5426905
Gene: Rgs7  Location: Chr1:175059087-175492500 bp, - strand  Genetic Position: Chr1, 81.11 cM
Rgs7tm1Cjch/Rgs7tm1Cjch Rgs11tm1Lex/Rgs11tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184922
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 6 through 8. Western blot analysis confirmed the absence of protein expression in the retina and cerebellum. (J:184922)
Generation of the Rgs7tm1Cjch allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs7 Mutation:  16 strains or lines available
References
Original:  J:184922 Shim H, et al., Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice. J Biol Chem. 2012 Apr 27;287(18):14873-9
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory