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Arg1tm1Ekoe
Targeted Allele Detail
Summary
Symbol: Arg1tm1Ekoe
Name: arginase, liver; targeted mutation 1, Eleonore Kohler
MGI ID: MGI:5426515
Synonyms: Arg1F
Gene: Arg1  Location: Chr10:24791105-24803368 bp, - strand  Genetic Position: Chr10, 12.26 cM
Alliance: Arg1tm1Ekoe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183882
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 4 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of exon 4. (J:183882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arg1 Mutation:  25 strains or lines available
References
Original:  J:183882 Van den Bossche J, et al., Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol. 2012 May;91(5):685-99
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory