Tg(CD2-Ppp2ca)#Gct
Transgene Detail

Summary

• Symbol: Tg(CD2-Ppp2ca)#Gct
• Name: transgene insertion, George C Tsokos
• MGI ID: MGI:5426510
• Transgene: Tg(CD2-Ppp2ca)#Gct Location: unknown
• Alliance: Tg(CD2-Ppp2ca)#Gct page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Ppp2ca)#Gct expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppp2ca (MGI:1321159)

• Mutation details: This transgene consists of the murine Ppp2ca coding sequence between the human CD2 promoter and locus control region. The pound symbol (#) is used when line is not specified and/or lines are pooled. Transgenic mice have five copies of the transgene that result in an approximate 30% increase in mRNA and protein levels.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:184067 Crispin JC, et al., Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012 Apr 15;188(8):3567-71
• All: 2 reference(s)