Nlrc5^tm1.1Ggaur
Targeted Allele Detail

Summary

• Symbol: Nlrc5^tm1.1Ggaur
• Name: NLR family, CARD domain containing 5; targeted mutation 1.1, Greta Guarda
• MGI ID: MGI:5426421
• Synonyms: Nlrc5^delta
• Gene: Nlrc5 Location: Chr8:95160984-95253900 bp, + strand Genetic Position: Chr8, 46.55 cM
• Alliance: Nlrc5^tm1.1Ggaur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184076
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Nlrc5^tm1Ggaur removed the neo cassette and exon 5. Western blot analysis confirmed the absence of protein expression in unstimulated and pIpC-treated bone marrow-derived macrophage. (J:184076)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc5 Mutation: 66 strains or lines available

References

• Original: J:184076 Staehli F, et al., NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol. 2012 Apr 15;188(8):3820-8
• All: 5 reference(s)