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Smad7tm1.1Ink
Targeted Allele Detail
Nomenclature
Symbol: Smad7tm1.1Ink
Name: SMAD family member 7; targeted mutation 1.1, Ingo Kleiter
MGI ID: MGI:5426017
Synonyms: Smad7fl
Gene: Smad7  Location: Chr18:75500600-75529006 bp, + strand  Genetic Position: Chr18, 51.06 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184670
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site followed by an frt-flanked neomycin (neo) resistance cassette upstream of the promoter regions and exon 1, and a second loxP site downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:184670)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad7 Mutation:  50 strains or lines available
References
Original:  J:184670 Kleiter I, et al., Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain. 2010 Apr;133(Pt 4):1067-81
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory