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Car5atm1Sly
Targeted Allele Detail
Nomenclature
Symbol: Car5atm1Sly
Name: carbonic anhydrase 5a, mitochondrial; targeted mutation 1, William S Sly
MGI ID: MGI:5425618
Gene: Car5a  Location: Chr8:121916135-121944912 bp, - strand  Genetic Position: Chr8, 70.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181790
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll of exon 3 as well as 150 bp of intron 2 and 3.05 kb of intron 3 were replaced by a PGK-neomycin resistance gene. This removed two of the three zinc binding histidine residues and created a frameshift beginning in exon 4. No protein was detected by Western blot analysis. (J:181790, J:196135)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Car5a Mutation:  11 strains or lines available
References
Original:  J:181790 Price TO, et al., Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. Endocrinology. 2012 Jan;153(1):362-72
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory