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Mns1tm1Jw
Targeted Allele Detail
Nomenclature
Symbol: Mns1tm1Jw
Name: meiosis-specific nuclear structural protein 1; targeted mutation 1, Jeremy Wang
MGI ID: MGI:5425368
Gene: Mns1  Location: Chr9:72345103-72366036 bp, + strand  Genetic Position: Chr9, 40.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183398
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 - 8 were replaced with a floxed neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in testes and trachea from homozygous mice. (J:183398)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mns1 Mutation:  11 strains or lines available
References
Original:  J:183398 Zhou J, et al., MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet. 2012 Mar;8(3):e1002516
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/09/2021
MGI 6.17
The Jackson Laboratory