Pmp22^Mhdatre002
Chemically induced Allele Detail

Summary

• Symbol: Pmp22^Mhdatre002
• Name: peripheral myelin protein 22; tremor mutant 002
• MGI ID: MGI:5425012
• Synonyms: Pmp22^TRE002, TRE002
• Gene: Pmp22 Location: Chr11:63019808-63050373 bp, + strand Genetic Position: Chr11, 38.99 cM
• Alliance: Pmp22^Mhdatre002 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for metabolic bone disease as part of the Munich ENU Mutagenesis Project. The molecular lesion is a mutation in exon 4 of the gene, altering nucleotide 206 from T-to-A in codon 69, predicted to result in an amino acid change from Methionine to Lysine (M69K). (J:82809)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pmp22 Mutation: 32 strains or lines available

References

• Original: J:183993 Sabrautzki S, et al., New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012 Aug;23(7-8):416-30
• All: 2 reference(s)