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Mirc21tm1.1Aven
Targeted Allele Detail
Nomenclature
Symbol: Mirc21tm1.1Aven
Name: microRNA cluster 21, including Mir34c through Mir34b; targeted mutation 1.1, Andrea Ventura
MGI ID: MGI:5320799
Synonyms: miR-34b~c-, Mir34b/Mir34ctm1.1Aven
Gene: Mirc21  Location: Chr9:51014334-51014945 bp  Genetic Position: Chr9, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188152
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA targeting vector was designed to replace the microRNA 34b (miR-34b) and miR-34c sequence with a frt-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the neo cassette. (J:188152)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc21 Mutation:  5 strains or lines available
References
Original:  J:188152 Concepcion CP, et al., Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet. 2012 Jul;8(7):e1002797
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory