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Mir34atm1.2Aven
Targeted Allele Detail
Summary
Symbol: Mir34atm1.2Aven
Name: microRNA 34a; targeted mutation 1.2, Andrea Ventura
MGI ID: MGI:5320795
Synonyms: miR-34afl
Gene: Mir34a  Location: Chr4:150152911-150153012 bp, + strand  Genetic Position: Chr4, 80.85 cM
Alliance: Mir34atm1.2Aven page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188152
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of the sequence, and a frt-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of the sequence. Flp-mediated recombination removed the neo cassette and left the sequence floxed. (J:188152)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir34a Mutation:  9 strains or lines available
References
Original:  J:188152 Concepcion CP, et al., Intact p53-dependent responses in miR-34-deficient mice. PLoS Genet. 2012 Jul;8(7):e1002797
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory